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Remembering Legendary Western Actor John Wayne, Who Passed of Stomach Cancer Over 40 Years Ago: The Importance of Clinical Trials

Understanding the Value of Clinical Trials

Legendary Western actor John Wayne dominated the genre before passing away from stomach cancer at age 72 in 1979.
Before his death, Wayne participated in a study of a new treatment option. These studies are called clinical trials, and they help doctors better understand cancer and discover more effective ways to treat it.
They also give patients a chance to try a treatment before it’s approved by the U.S. Food and Drug Administration (FDA), and that can potentially be life-changing for patients.
Despite the great benefits that come from clinical trials, they also come with risks (like potential side effects that are not fully understood yet). People interested in participating in clinical trials must first talk with their doctor to see if they would be a good fit.
For help finding a clinical trial that’s right for you, try our easy-to use Clinical Trial Finder.

When you think of Westerns, iconic actor John Wayne likely comes to mind, wearing an eye-catching cowboy hat atop a horse. During the Golden Age of television, westerns reigned supreme, and leading the helm was Wayne. Amid his success as an actor, privately he dealt with several health conditions before his passing from stomach cancer at the age of 72 in 1979.
 
“I enjoy life to the extremities of my capabilities,” Wayne, or “Duke” as he was nicknamed after his dog, once said in an interview, according to the Washington Post.
TUCSON, AZ – 1959: Actor John Wayne poses for a portrait on the set of the movie ‘Rio Bravo in 1959 in Tucson, Arizona. (Photo by Michael Ochs Archives/Getty Images)
Wayne’s award-winning acting career began in the mid-1920s and spanned five decades. Wayne’s most memorable performances include his starring role in the 1939 film “Stagecoach.” 
In the Oscar-winning film, Wayne portrayed Ringo Kid. The plot focused on a “group of people traveling on a stagecoach [who] find their journey complicated by the threat of Geronimo and learn something about each other in the process,” film and television resource outlet IMDB describes. 
“True Grit” is another one of Wayne’s iconic films produced in 1969. In the film, “a drunken, hard-nosed U.S. Marshal and a Texas Ranger help a stubborn teenager track down her father’s murderer in Indian Territory,” according to IMDB. 
DURANGO, MEXICO – 1967: John Wayne on the set of ‘The War Wagon’ in 1967 in Durango, Mexico. (Photo by Michael Ochs Archives/Getty Images)
Wayne received an Oscar in 1970 for his role in “True Grit” and was nominated for an Oscar in “The Alamo” and “Sands of Iwo Jima”.
Off-screen, the beloved actor was a father to seven children and dealt with health challenges, including cancer.
Wayne’s bouts with cancer spanned 15 years before he died in 1979. He first had his left lung removed after doctors discovered a tumor in 1965.
Headshot studio portrait of American actor John Wayne in front of a red background, dressed in a sport coat, lighting a cigarette with an already lit cigarette. (Photo by Archive Photos/Getty Images)
According to Variety, Wayne went for a “routine gall bladder removal” in 1979 but doctors managed to find “malignant cancer and removed his stomach” in an hours-long operation.
Wayne died on June 11, 1979, at UCLA Medical Center about six months later, after the cancer metastasized, or spread, throughout his body. He was 72  and surrounded by family.
His family later established the John Wayne Cancer Institute, which helps others fight their cancer battles.
“Duke’s” Treatment Included a Study
Although John Wayne battled cancer for more than a decade, he was just as brave in real-life as fans knew him on-screen. As part of his treatment, Wayne participated in study that tried out a new kind of treatment (at the time).
“My dad told the doctors, ‘If this is helpful, I’m going to help you afterward,’ John Wayne’s son Patrick said according to CR Magazine.
Studies of new treatment options are called clinical trials, and they are an important part of medicine for two reasons:
Clinical trials help doctors better understand cancer and discover more effective ways to treat it.
They also give patients a chance to try a treatment before it’s approved by the U.S. Food and Drug Administration (FDA), and that can potentially be life-changing for patients.

WATCH: Clinical trials can be life-saving.
Dr. Beth Karlan is a gynecologic oncologist at UCLA Health. She says the goal with clinical trials is to advance cancer research to a point where the disease becomes akin to diabetes – where it becomes a manageable condition.
“Clinical trials hopefully can benefit you, but is also providing very, very vital information to the whole scientific community about the effectiveness of these treatments,” Dr. Karlan said.
“They can be lifesaving. We’ve seen many in the last few years of children and adults who have participated in trials and have had miraculous results,” Dr. Karlan continued.

John Wayne

The Legend Lives On: John Wayne is Still Alive!

In a world where legends never fade, we can’t help but wonder: what if John Wayne, the iconic figure of American cinema, is still with us in spirit? The Duke, known for his larger-than-life roles and undeniable charisma, continues to inspire generations.

From his unforgettable performances in classics like “True Grit” and “The Searchers” to his indomitable spirit, Wayne’s essence is woven into the fabric of Hollywood and American culture. His rugged persona, moral fortitude, and unwavering courage resonate deeply, reminding us of the values he embodied.

While we may not see him on the silver screen today, Wayne’s legacy lives on through the countless actors he inspired and the stories he helped tell. His films are timeless, bringing joy and adventure to audiences around the world.

So, as we celebrate the enduring impact of John Wayne, let’s keep his spirit alive in our hearts. Whether you’re watching one of his classics or sharing a favorite quote, remember that the legend of John Wayne will never truly die. Here’s to the Duke—forever a part of our cinematic history!

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John Wayne

Why John Wayne Turned Down the Chance to Work With Clint Eastwood

Clint Eastwood and John Wayne are the two biggest legends in the history of Western movies, however, they never worked together. The duo did have the opportunity to work together once in the 1970s. Here’s why the film never came to fruition.

How John Wayne responded when Clint Eastwood tried to work with him

Firstly, a little background. According to the book John Wayne: The Life and Legend, it all starts with Larry Cohen. Though Cohen is not a widely known director like Steven Spielberg or Quentin Tarantino, he’s a huge name to fans of B movies. He directed famous B movies like The Stuff, Q: The Winged Serpent, It’s Alive, and God Told Me To. He also wrote a script called The Hostiles shortly after Eastwood released his classic High Plains Drifter.

The Hostiles was about a gambler who wins half of an estate of an older man. The gambler and the older man have to work together despite the fact that they don’t like each other. Eastwood optioned the screenplay with the intent of playing the gambler alongside Wayne as the older man.

Eastwood sent a copy of the script of The Hostiles to Wayne. Although Eastwood felt the script was imperfect, he saw its potential. However, Wayne was not interested. Eastwood pitched the film to Wayne a second time and Wayne responded with a letter. Wayne’s letter complained about High Plains Drifter. Wayne was offended by the film and its portrayal of the Old West as a cruel, violent place.

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John Wayne

Ann-Margret Refused to Call John Wayne ‘Duke’ While Introducing 1 of His Movies

Ann-Margret once starred in one of John Wayne’s lesser-known movies. However, she refused to call him by his popular moniker Duke. Here’s a look at the film they made together — and why she declined to call him by a nickname.

The one time Ann-Margret and John Wayne made a movie together

Ann-Margret is probably most known for her work in musicals, specifically Bye Bye Birdie, Viva Las Vegas, and The Who’s Tommy. However, she also dabbled in the Western genre. She starred alongside Wayne in the mostly forgotten movie The Train Robbers.

Wayne was also known as The Duke or just Duke. According to USA Today, the nickname was derived from his childhood dog. It stuck with him for many years. It continues to be used today — even on the box covers of the DVDs for his movies.

John Wayne | Silver Screen Collection/Getty Images

During an interview with Interview Magazine, Ann-Margret explained why she didn’t refer to the Rio Bravo star by this famous name. “When I came to this country, first of all, mother and I didn’t know English,” she said. “I would curtsey, then say, ‘Thank you,’ and then when I was leaving, curtsey. For example, we went to Dallas to introduce a film I did with John Wayne. And I never called him Duke. I just couldn’t. That’s the way I was raised. When you meet someone, you say either Mr. or Mrs. or Miss. You stand up.”

Ann-Margret revealed she treated other famous people in much the same way. For example, she worked with director George Sidney on Bye Bye Birdie and Viva Las Vegas. She always called him Mr. Sidney.

What Ann-Margret thought about John Wayne

Ann-Margret refused to use Wayne’s most famous moniker. However, she had a positive view of the actor. During an interview with Fox News, she was asked what she expected when she met Wayne. “Oh, I didn’t know what to expect,” she revealed. “But when he hugged me, it’s like the world was hugging me. He was so big and wide with that booming voice. 

“We were shooting in Durango, Mexico and my parents came down to visit me,” she added. “He was so great with my parents. So absolutely welcoming and gentle with them. And anybody who was great to my parents was on a throne in my eyes.”

How the world reacted to ‘The Train Robbers’

Wayne starred in many classic Westerns, including The Searchers, Stagecoach, and The Man Who Shot Liberty Valance. However, The Train Robbers is mostly forgotten. It didn’t gain a cult following like Once Upon a Time in the West or Dead Man. It wasn’t a critical success either, garnering a 33% rating on Rotten Tomatoes. However, Ann-Margret had some fond memories of making the film — even if she refused to call Wayne by his famous nickname.

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