Ariana Grande has always been a beloved figure in the entertainment industry, admired for her talent, stunning looks, and relatable personality.

However, recent public appearances have sparked concern among fans.

“Scarily skinny”

Ariana Grande has been a household name ever since she rose to fame as a child star on Victorious. Over the years, she’s undergone various transformations, both professionally and personally. But her most recent change — marked by a noticeable weight loss — has certainly captured the attention of fans in a big way.

When Ariana Grande graced the red carpet at the BAFTA Film Awards, the internet quickly flooded with comments about her appearance once again.

The 31-year-old pop star can’t seem to avoid the endless online discussions about her body every time she steps into the public eye.

A recent photo of her signing autographs at the BAFTAs sparked fans to label her as “scarily skinny” and “terribly thin.”

“Terribly thin. I hope she can turn this around before it’s too late. I’m sure her organs are working overtime,” read one comment.

Another said, “She suffers from anxiety and this picture actually looks as if she is getting better. She was smaller than this at one point.”

“I hope she’s okay. She doesn’t look well,” another wrote. “…Something is up.”

Many quickly speculated that Ariana Grande’s appearance was the result of an eating disorder (ED).

”There is Hollywood skinny then there’s not ok skinny and she is not ok that is alarming skinny,” one commenter wrote.

“This is anrexia,” one person remarked, while another agreed, saying, “Damn, she’s anrexic. She needs help as soon as possible. Before her heart stops.”

“This is actually getting really concerning,” a fan added. “Every time she’s out and about she looks like she’s getting skinnier. To the people saying she’s fine, no she isn’t, this is the purest example of an*rexia there is.”

“She clearly has an ED and she needs help,” another said. “She’s scarily skinny these days … Atp she’s just skin and bones.”

Dr. Patrick Wanis, a behavioral and relationship expert, explained that much of the constant commentary on Ariana Grande’s appearance is driven by what psychologists call a “parasocial relationship”—a one-sided emotional attachment fans develop to a celebrity, even though the celebrity has no awareness of their existence.

“Ariana Grande became famous as a Nickelodeon child star around age 17. The public has grown up with her and sees her through the lens of nostalgia, purity, and a fixed image of youth,” Dr. Wanis shared in an email to Bored Panda.

“Accordingly, any physical change—weight loss, weight gain, or aging—is magnified because people expect her to remain the same forever. Her fans identify with her youth.”

The issue of weight loss in the entertainment industry has long been a topic of debate. Celebrities like Christina Aguilera, Katy Perry, and many others often make headlines for any weight fluctuations, whether gain or loss.

Celebrities, particularly women, often face immense pressure to meet unrealistic body standards, which can lead to unhealthy weight loss practices.

While Grande has not publicly addressed the concerns about her health, her fans are urging her to take care of herself and prioritize her wellbeing.

“The public expects female celebrities to strike an impossible balance—thin but not ‘too thin,’ toned but not ‘too muscular,’ natural but not ‘too real.’ This is an extension of the extraordinary pressure and societal expectation of women,” Dr. Wanis explained.

This “toxic mix of nostalgia, beauty standards, and social media culture” creates immense pressure on Grande and other pop stars to “remain frozen in time – eternally youthful, while still conforming to impossible expectations of unattainable standards if not perfection,” said Dr. Wanis, the creator of SRTT Therapy (Subconscious Rapid Transformation Technique).

Ariana’s journey has been an open one, from overcoming personal struggles to finding her voice in an often demanding industry. Her fans admire her resilience, but they are also quick to remind her that she deserves to be healthy and happy above all else.

As the discussion continues, it’s clear that her fans’ priority is her physical and mental health, and they will be waiting for updates from the star, hoping to see her flourish in every aspect of her life.

Even though many cancer therapy technologies have been developed, all modern cancer medicines aim to eradicate cancer cells. However, this strategy has serious drawbacks, including as the potential for cancer cells to become resistant and reappear, as well as serious adverse effects from the death of healthy cells.

On December 20, KAIST (represented by President Kwang Hyung Lee) declared that a research team headed by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering had created a novel treatment for colon cancer that can prevent side effects by transforming cancer cells into a state similar to healthy colon cells without killing them. Advanced Science published the research.

The study team concentrated on the finding that normal cells regress along their differentiation trajectory during the oncogenesis process. Building on this realisation, scientists created a method to produce a digital replica of the gene network linked to normal cells’ differentiation trajectory.

The group methodically found master molecular switches that promote normal cell differentiation using simulation research. Molecular and cellular research, as well as animal studies, have proven that when these switches were administered to colon cancer cells, the cancer cells returned to a normal-like condition.

Instead of depending on chance findings, this study shows that cancer cell reversion can be methodically accomplished by examining and applying the digital twin of the cancer cell gene network.

The results have great potential for creating reversible cancer treatments that can be used to treat different kinds of cancer. “It is a remarkable phenomenon that cancer cells can be transformed back into normal cells,” said Professor Kwang-Hyun Cho. This work demonstrates that it is possible to systematically generate such reversion.

He added, “By turning cancer cells back into healthy cells, this study presents the innovative idea of reversible cancer treatment. Through the methodical examination of typical cell development trajectories, it also creates the fundamental technology for determining targets for cancer reversion.

The National Research Foundation of Korea and the Ministry of Science and ICT provided funding for the study through the Basic Research Laboratory Program and the Mid-Career Researcher Program. The research results have been turned over to BioRevert Inc., which will use them to create useful cancer reversion treatments.

Our knowledge of mitochondrial function and how it affects health and illness can be improved by measuring cellular oxygen consumption rates, or OCR. Making sure OCR measurements are accurate is essential for lab managers in charge of mitochondrial research. OCR measurements can be distorted by factors including cell count, mitochondrial mass, and media components, which might mean the difference between ground-breaking discoveries and false findings.

Recent technological developments have made it possible to detect OCR in living cells during the course of an experiment in a long-term, high-throughput manner. This ability can offer fresh perspectives on how cells divide, metabolise, differentiate, and react to stress in dynamic environments.

This white paper offers a thorough overview of OCR normalisation techniques, including as flow cytometry, protein-based, DNA content, and microscopy methods. In order to account for factors and uncover significant differences from your data, it discusses both internal and external normalisation strategies. Your lab can improve the accuracy of OCR measurements and gain a better understanding of mitochondrial function and its role in both health and illness by implementing these best practices.

A fourth child from the same family has passed away days following an apparent murder-suicide involving Wyoming mother Tranyelle Harshman.

Tragic reports previously detailed how Harshman allegedly shot her four daughters before turning the gun on herself on February 10, 2025.

Brailey Blackmer, 9, Brooke and Jordan Harshman, both 2, and Tranyelle herself died from their injuries. 7-year-old Olivia Blackmer was airlifted to a hospital in Salt Lake City, with people all over the world praying for her recovery when the story gained international attention.

Sadly, father Quinn Blackmer posted to Facebook on Sunday, February 16, that Olivia had lost the battle for her life.

“I know this isn’t the update people were hoping for and we are absolutely gutted to make it, but we needed time to process what had happened before we let the world know of the tragic passing of Olivia yesterday (February 15) afternoon at 3:44 pm,” Quinn wrote.

“The amount of devastation we feel and are going through is so much. Please give all famlies involved our time time and space during this extremely difficult time in our life.”

Quinn added that he was taking some small amount of solace in the fact that his daughters are together.

“The peace I find is knowing that my babies don’t have to be apart from each other and they can also be with their other sisters,” he said.

According to reports, Tranyelle Harshan, 32, was suffering from postpartum depression, post-traumatic stress disorder, and depression. On the day of the alleged murders, she called the police to confess to having shot her daughters, warning them that she planned to then do the same to herself.

Tranyelle’s partner, Cliff Harshman, told the Cowboy State Daily that she had been suffering greatly.

“My wife was not a monster,” he said.

Of her health battles, he shared: “Most people don’t understand how that affects the brain. It’s a chemical imbalance. And it can be exacerbated by trying to fix it with medication.”

Rest in peace to the poor children taken from this world too soon.